About Research in Wellcome Trust Research Laboratory
Sl No. ONGOING GRANTS FUNDING AGENCY DESCRIPTION
1 Rotavirus Surveillance in the South East Asia (SEA) Region World Health Organization, South East Asia Regional Office The Rotavirus Reference Laboratory provides quality control, genotyping and training for laboratories in the SEA region.
2 Impact Assessment Study of Rotavirus Vaccine Linked to the National Rotavirus Surveillance and Intussusception Surveillance in India Bill and Melinda Gates Foundation, USA To generate data on effectiveness and impact of rotavirus vaccines through Universal Immunization Programme in early introducing regions of India (Odisha, Andhra Pradesh, Haryana and Himachal Pradesh) and to establish a sentinel site-based platform for assessment of safety of the vaccine with respect to intussusception. The effectiveness and impact evaluations will be built on the existing infrastructure of the National Rotavirus Surveillance Network (NRSN), a national network of sentinel hospital-based sites across India conducting AGE surveillance, with strengthening of sites included for impact assessment in early introducing states.
3 Testing the feasibility of integrated approaches to interrupt the transmission of soil-transmitted helminths (STH) The Natural History Museum, London, UK The trial findings and accompanying implementation science research will provide the evidence necessary for optimizing a delivery model that can inform future guidelines, policies, and operational plans in countries with high STH burden.
4 Building enteric infectious disease research capacity in India Fogarty International Centre, National Institute of Health (NIH), USA The overall goal of this project is to enhance research and training activities in enteric infectious disease at the Christian Medical College, Vellore.
5 National Surveillance System for Enteric Fever in India Bill and Melinda Gates Foundation, USA This study will establish a national surveillance system for enteric fever in India. Percentage of time devoted
6 Systems vaccinology of the Vi conjugate typhoid vaccine in infants Department of Biotechnology, New Delhi The aim of this study is to understand the impact of antibiotic usage on gut bacteria and its impact on the immune response to Typbar-TCV® vaccine, a licensed vaccine against typhoid which can be used in children.
7 Environmental surveillance for typhoid in Tamil Nadu, Bill and Melinda Gates Foundation, USA This project is aimed to initiate environmental surveillance in the community (urban and rural) using molecular approaches for OPV 1 and 3 from sewage samples. Salmonella Typhi from sewage and from environmental samples of households of persons with typhoid fever and a limited survey of antimicrobial resistance genes from sewage, food, water and animal and farm produce in the community.
8 Immunogenicity and Safety of Rotavac and Rotasiil Administered in an interchangeable dosing schedule among healthy Indian Infants: A multicentric, Phase IV, Open-Labeled, Randomized, Controlled Trial Indian Council of Medical Research, New Delhi This study will measure the impact of immune response and safety profile if the vaccines are used interchangeably in the 3-dose schedule
9 Smartphone based self-reporting system for the assessment of catastrophic health expenditures – a participatory approach to household surveys. Department of Science & Technology, New Delhi -
10 Identification of enteric pathogens in diarrheal specimens from children who participated in the Rotasiil efficacy trial and their effect on vaccine efficacy estimates for Rotasiil Program for Appropriate Technology in Health, USA This project aims to describe the infectious agents, other than the rotavirus virus, detected in diarrheal episodes in infants/children who participated in a clinical trial for the licensure of the oral rotavirus vaccine, Rotasiil®. It also aims to assess if accounting for these coinfecting agents modifies the estimated efficacy of the vaccine considerably.
11 Rotasiil vaccine effectiveness, rotavirus gastroenteritis and intussusception surveillance study in Jharkhand, India Program for Appropriate Technology in Health, USA This study will help us delineate the possible infectious etiologies of Intussusception among children less than two years of age.
12 Rotasiil vaccine intussusception surveillance in Kerala, Karnataka, Maharashtra and Gujarat, India Bill and Melinda Gates Foundation, USA The study will generate information useful to public health officials and to national government and help to demonstrate the safety of Rotasiil® vaccine in public health practice
13 Surveillance and Pregnancy / Perinatal Research Platform for India Bill and Melinda Gates Foundation, USA The aim of this study is to generate surveillance data to improve understanding of the burden of adverse pregnancy and perinatal conditions and to inform a future pregnancy risk stratification algorithm
14 Intracellular survival of S. Typhi in environmental Acanthamoeba Bill and Melinda Gates Foundation, USA This project aims to examine intracellular survival of the bacteria responsible for typhoid fever in a free living parasite called Acanthamoeba
15 PRERNA 2.0 – GRANT ID INV – 003342 Bill and Melinda Gates Foundation, USA To establish a collaborative platform model for family health research and vaccine research by continuing and enhancing the partnership between three Indian institutions that have complementary strengths and a proven track record of working together effectively.
16 Costing of diarrhoeal/febrile illness among under five children in Vellore Senior Research Fellowship, Indian Council of Medical Research, New Delhi The main objective of the study is to find out the cost of illness of diarrhoea and of fever in an under five child in India.
17 Molecular and epidemiological characterization of rotaviruses Senior Research Fellowship, Department of Biotechnology, New Delhi The purpose of the study is to understand why certain kinds of viruses are present in specific populations and how they change or spread over time
18 Understanding the effects of initiation of complementary feeding at four months compared to six months on growth and infection among Indian children DBT-BIRAC-BMGF ki Data Challenge for Maternal and Child Health" under Grand Challenges India This is a SECONDARY DATA ANALYSIS of pooled cohorts, the data being provided by the ki' Data Challenge for Maternal and Child Health, jointly funded by BIRAC (Biotechnology Industry Research Assistance Council), Department of Biotechnology (DBT), Ministry of Science and Technology, Government of India and Bill & Melinda Gates Foundation (BMGF).
19 Effect of Community Wide Deworming on Hookworm Modulated Immune Responses to Bystander Antigens and Vaccines in Southern India Fogarty International Centre, National Institute of Health (NIH), USA The overall goal of this study, is to determine the impact of large scale community-wide deworming and the potential break in transmission of hookworm on immune response to unrelated pathogens and to vaccines