Research

  • Ongoing Studies
  • Grants Completed from 2005
  • Publications
Sl No. ONGOING GRANTS FUNDING AGENCY DESCRIPTION
1 Comprehensive Investigation into the Risk Factors of Malnutrition and the Consequences for Child Health Foundation for the National Institutes of Health This multi-site cohort study investigates symptomatic and asymptomatic enteric infections, gut function, nutrition, and physical and cognitive development in children in an urban area of Vellore from birth to three years of age.
2 Rotavirus Surveillance in the SEA Region World Health Organization, South East Asia Regional Office The Rotavirus Reference Laboratory provides quality control, genotyping and training for laboratories in the SEA region.
3 Bovine Rotavirus Vaccine Development PATH A clinical testing laboratory has been established for the phase III rotavirus vaccine trial for the UK bovine candidate being developed by Serum Institute of India Ltd.
4 National Hospital Based Rotavirus Surveillance Network Indian Council of Medical Research The expanded hospital and laboratory rotavirus surveillance network across multiple sites in India estimates the proportion of rotavirus in children with acute gastroenteritis. External quality assurance for the network is conducted in coordination with the National Institute of Epidemiology.
5 Treatment of Enteric Infections among Indian Infants to Improve their Response to Oral Poliovirus Vaccine Bill and Melinda Gates Foundation The study will investigate whether children between the ages of six months and one year who have not responded to oral poliovirus vaccine respond after a course of antibiotics.
6 Intestinal and Milk Glycan Expression in the Restriction of Neonatal Infection National Institutes of Health This study examines the role of sugars on the surface of cells in determining the ability of viruses to enter cells. Experimental studies that examine virus binding and blocking of that binding by small sugars or antibodies will be followed by testing of samples from Indian children and their mothers to see what sugars they have on cells and in breast milk and how that influences infection and disease.
7 B and T Cell Responses to Rotavirus Infection and Vaccination in Indian Infants Department of Biotechnology The study will better characterize immune responses to primary and secondary rotavirus infection and vaccination in Indian infants.
8 Facilitation of the Indian National Rotavirus Surveillance Program Bill and Melinda Gates Foundation The Rotavirus Reference Laboratory provides quality control, genotyping and training for laboratories in the region.
9 Fund for Improvement of S&T Infrastructure in Universities and Higher Educational Institutions (FIST) Department of Science and Technology Through this grant Technai Elecron Microscope was purchased to enhance research and teaching.
10 Tufts-CMC Framework Program for Global Health Innovation National Institutes of Health, USA The goal of this training program is to train post-doctoral fellows from Tufts and CMC in interdisciplinary global health innovations.
11 Family Health Research Platform Bill and Melinda Gates Foundation To establish a collaborative platform model for family health research and vaccine research by continuing and enhancing the partnership between three Indian institutions that have complementary strengths and a proven track record of working together effectively
12 Early implementation to rollout of rotavirus vaccine in the public health system under monitoring Bill and Melinda Gates Foundation To establish a system of reporting IS cases from hospital surveillance in three sites. To assess all safety aspects related to ROTAVAC immunization
13 Susceptibility and development of protective immunity to norovirus in a South Indian birth cohort Bill and Melinda Gates Foundation To investigate age-specific incidence of norovirus from birth to three years. The protective effect of norovirus infection on subsequent norovirus disease. The association of secretor status (as determined by FUT2 genotype) with norovirus susceptibility. The association of norovirus antibodies (IgG and IgA) and histoblood group blocking antibody with infection and disease risk
14 Impact of maternally derived antibodies and infant microbiota on the immunogenicity of rotavirus vaccines in African, Indian and European infants Department of Biotechnology To investigate key maternal and infant factors that may reduce rotavirus (RV) vaccine performance in infants living in low income countries
15 Impact Assessment Study of Rotavirus Vaccine Linked to the National Rotavirus Surveillance and Intussusception Surveillance in India Bill and Melinda Gates Foundation To generate data on effectiveness and impact of rotavirus vaccines through Universal Immunization Programme in early introducing regions of India (Odisha, Andhra Pradesh, Haryana and Himachal Pradesh) and to establish a sentinel site-based platform for assessment of safety of the vaccine with respect to intussusception. The effectiveness and impact evaluations will be built on the existing infrastructure of the National Rotavirus Surveillance Network (NRSN), a national network of sentinel hospital-based sites across India conducting AGE surveillance, with strengthening of sites included for impact assessment in early introducing states.
Sl No. COMPLETED GRANTS FUNDING AGENCY DURATION
1 Anti-helminthic Drug Resistance in India - Assessment of Benzimidazole Resistance in Clinical Isolates of Hookworm by Detection of β Tubulin Gene Polymorphisms and in vitroAssays Indian Council of Medical Research 2012-2015
2 Building Enteric Infectious Disease Research Capacity in India Fogarty International Center 2010-2015
3 Immune Response to Cryptosporidiosis in a Birth Cohort of Children in South India National Institute of Allergy and Infectious Diseases 2009-2015
4 Predictors of Poor Immune Response to Rotavirus Vaccine in Infants Department of Biotechnology and Research Council of Norway 2012-2014
5 Effect of Inactivated Poliovirus Vaccine on Gut Immunity against Poliovirus in Children who have received Oral Polio Vaccine Bill and Melinda Gates Foundation 2012-2014
6 Effect of Probiotic and Zinc Supplementation on Systemic Immune Response to Oral Rotavirus and Oral Poliovirus Vaccination Department of Biotechnology 2011-2014
7 Supplementation with Zinc and/or Probiotics to Enhance the Immune Response of Oral Rotavirus and Polio Vaccines in Indian Infants PATH 2011-2014
8 Development of a Chip for Studying Human Fecal Microbiota Composition and Activity and its Application in Patients with Inflammatory Bowel Disease Department of Biotechnology 2011-2014
9 Fund for Improvement in S&T Infrastructure Department of Science and Technology 2009-2014
10 HIV, ART and Intestinal Microbiota National Institute of Allergy and Infectious Diseases 2011-2013
11 Prevalence of Ceilac Disease in Indigenous Populations of Southern, Northern and North-Eastern Parts of India and Identification of Reasons for Difference in its Prevalence Indian Council of Medical research 2011-2013
12 Epidemiology of Novel Human Astroviruses National Institute of Allergy and Infectious Diseases 2011-2013
13 Establishment of Core Vaccine Research Unit (CVRU) Department of Biotechnology 2010-2013
14 Clinical immunology laboratory assays in PVS’ ongoing Advancing Rotavirus Vaccine Development (ARVAC) Project PATH 2010-2013
15 An Open Label Post Licensure Trial to Evaluate the Safety and Immunogenicity of Indigenously Manufactured Killed Bivalent (O1 and O139) Whole Cell Oral Cholera Vaccine (Shanchol) International Vaccine Institute 2012
16 Phase III Randomized Double Blind Placebo Controlled Trial to Evaluate the Protective Efficacy of Three Doses of Oral Rotavirus Vaccine (ORV) 116E against Severe Rotavirus Gastroenteritis in Infants Department of Biotechnology, PATH 2010-2012
17 Probiotics for Infectious Diarrhea in Children in South India Indian Council of Medical Research 2010-2012
18 Immunological Assays of BRV and a Reference Laboratory PATH 2010-2012
19 Meta-genomic Study of the Fecal Anaerobic Bacteria Flora in Healthy Rural South Indian Subjects Department of Biotechnology 2009-2012
20 Cryptosporidial Species, Cpgp 40/15 Polymorphisms and Oocyst Burden Associated with Diarrhea in HIV Infective Patients in South India Indian Council of Medical Research 2009-2012
21 Planning for the Delivery of a More Effective Oral Rehydration Solution to Improve Diarrhea Control Worldwide Bill and Mellinda Gates Foundation 2009-2012
22 Transmission Dynamics of Cryptosporidial Infections in India National Institute of Allergy and Infectious Diseases 2008-2012
23 Development of the Intestinal Bacterial Flora in the Neonate in South India: Molecular Analysis Indian Council of Medical Research 2008-2012
24 Production and Delivery of Antibody Fragments Against Pathogens by Lactobacilli European Union 2008-2012
25 Evaluation of Serum Mannose Binding Lectin and Exposure to Cryptosporidiosis in Children Participating in a Study on Routine Administration of Folic Acid and Vitamin B12 to Prevent Childhood Infections Thrasher Research Fund 2008-2012
26 Genetic Susceptibility and Innate Immunity to Cryptosporidium Infections in Childhood – A Candidate Gene approach Indian Council of Medical Research 2009-2011
27 Impact of Demographic and Social Change on Gastroenteric Viral Infections UK India Education and Research Initiative, British Council 2009-2011
28 Hospital-based Randomized Control Trial of Racecadotril in Acute Diarrheal Disease in Children 6 Months to 5 Years of Age Swedish International Development Agency 2008-2011
29 Community-based Randomized Control Trial of Racecadotril in Acute Diarrheal Disease in Children 6 Months to 5 Years of Age Swedish International Development Agency
30 FUT2 and ABO Gene Polymorphisms in Determination of Susceptibility to Noroviral Infection Indian Council of Medical Research 2008-2011
31 Analysis of NOD2 Gene Defects in Indian Patients with Crohn’s Disease Department of Science and Technology 2008-2011
32 Esterified Starch and Oral Rehydration Solution as a Treatment for Acute Infectious Diarrhea Department of Biotechnology 2008-2011
33 Investigation of TLR Mediated Innate Immune Response to Cryptosporodium parvum in Human Intestinal Epithelial Cell Lines Using siRNA Based Post Transcriptional Silencing Department of Biotechnology 2008-2011
34 Phase I/II Randomized Double Blind Placebo-controlled, Dosage Selection Study to Evaluate the Safety, Tolerability and Immunogenicity of a 3 Dose Series of Live Attenuated Tetravalent (G1-G4) Bovine-Human Reassortant Rotavirus Vaccine (BRV-TV) Administered to Healthy Indian Infants Shantha Biotechnics Limited 2010
35 A Comparative Study of Inflammation Bowel Disease in India and the United States to Assess Environmental Risk Factors and Gut Flora Crohn’s and Colitis Foundation of America 2009-2010
36 Characterization of Human Caliciviruses from India and Expression of Recombinant Capsid Proteins in Insect Cells using the Baculovirus System Department of Science and Technology 2007-2010
37 Nitric Oxide in Organophosphate Poisoning- Sources, Targets and Consequences South Asian Clinical Toxicology Research Collaboration 2007-2010
38 Pathophysiological Mechanisms in Oduvanthalai Poisioning – Identification of the Protein Target of Oduvanthalai South Asian Clinical Toxicology Research Collaboration 2007-2010
39 Cardiovascular Complications in Liver Cirrhosis: Role of Nitric Oxide and Mitochondria South Asian Clinical Toxicology Research Collaboration 2007-2010
40 Multi-disciplinary Research Training in Enteric Infections Fogarty International Center 2005-2010
41 Establishment of Hospital Based Surveillance for Rotavirus Disease and Strains in India Indian Council of Medical Research 2005-2010
42 Effect of Yoghurt Containing Bifidobacterium Lactis Bb-12 on Stool Frequency and Consistency and Fecal Microbiota in Healthy Adult Volunteers Chr Hansen 2009
43 An in vitro Study to Determine the Binding of Organophosphate Poisoned Patients Department of Biotechnology 2007-2009
44 Molecular Surveillance for Neonatal Rotavirus Disease and Strains Indian Council of Medical Research 2006-2009
45 Establishment of Hospital-based Surveillance for Rotavirus Disease and Strains in India Indian Council of Medical Research & Centers for Disease Control and Prevention 2005-2009
46 Efficacy of Albendazole in Reducing Fecal Egg Counts in Hookworm Infestation in Previously Treated Individuals World Health Organization 2008
47 Placental Mitochondria and Liver Damage in Acute Fatty Liver of Pregnancy Christian Medical College- National Center for Biological Sciences Collaboration 2007-2008
48 Role of Arginase in Modulating Nitric Oxide Signalling and Intestinal Damage during Liver Cirrhosis Department of Science and Technology 2005-2008
49 Induction of Glutathione Synthesis by Glutamine: Signalling Events and the Role of Mitochondria Council for Scientific and Industrial Research 2005-2008
50 Oxidative and Nitrosative Stress in the Pathogenesis of Inflammatory Bowel Diseases: Role of Mitochondria Council for Scientific and Industrial Research 2005-2008
51 Molecular Epidemiology of Cryptosporidiosis in India National Institutes of Health 2005-2008
52 Correlates of Protection against Rotaviral Gastroenteritis in Children in Vellore, India Wellcome Trust 2001-2008
53 Network R&D Proposal for Identification, Screening and Mass Production of Probiotic Strains and Placebos for Clinical Trials with an Aim to Future Post Trial-development and Marketing Department of Biotechnology 2005-2007
54 Characterization of Impaired Butyrate Oxidation by Colonic Epithelial Cells in Inflammatory Bowel Disease Indian Council of Medical Research 2005-2007
55 Comprehensive Studies of a New Improved Oral Rehydration Solution for Diarrhoeal Disease Wellcome Trust 2001-2007
56 Is the Increasing Incidence of Crohn’s Disease in a Low Prevalence Area Associated with Reduced Exposure to Infection with Hookworms? Broad Medical Research Program 2004-2006
57 Epidemiology of Human Calicivirus Infections in Acute Gastroenteritis and Food Borne Disease Indian Council of Medical Research 2003-2006
58 Effect of Probiotics on Pro-inflammatory Gene Activation and Barrier Disruption in Colonic Epithelial in Response to Enteropathogenic Bacteria Council for Scientific and Industrial Research 2003-2006
59 A Multicenteric Study on Surveillance and Molecular Characterization of Human Viruses (HcuCVs) from Cases of Acute Gastroenteritis Indian Council of Medical Research 2003-2006
60 Evaluation of Adult Stem Cells (Haematopoetic, Mesenchymal and Gastrointestinal Epithelial): Biopsy and Potential Application in Tissue Regeneration, Immune Modulation and as Vehicles for Gene Therapy Department of Biotechnology 2005
61 Hospital-based Retrospective Surveillance for Intussusception to Assess the Incidence of Intussusception in Children less than 5 Years of Age GlaxoSmithKline Biologicals 2004-2005
62 Replication of Study of Immunogenicity of a Candidate Vaccine Strain of Vibrio cholerae in South Indian Volunteers Department of Biotechnology 2004-2005
63 Planning Enteric Infection Research in Southern India Fogarty International Center 2004-2005
64 Macrophage Activation and Toll-like Receptors in Acute Infectious Colitis Council for Scientific and Industrial Research 2003-2005
65 Implications of Paediatric Gastrointestinal and Hepatic Infections for Public Health Policy and Practice in South India Higher Education Links Program, British Council 2002-2005
66 Molecular Genotyping of Cryptosporidium parvum from Symptomatic and Asymptomatic Patients with HIV Infection Tufts-Brown Fogarty AIDS International Research and Training Grant 2002-2005